A TLC Study of the lipophilicity of thirty-two acetylcholinesterase inhibitors — 1,2,3,4-tetrahydroacridine and 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives

Paweł Szymański, Robert Skibiński, Małgorzata Liszka, Izabela Jargieło, Elżbieta Mikiciuk-Olasik, Łukasz Komsta
2013 Open Chemistry  
AbstractThe lipophilicity of thirty-two novel acetylcholinesterase (AChE) inhibitors — 1,2,3,4-tetrahydroacridine and 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives was studied by thin layer chromatography. The analyzed compounds were chromatographed on RP-18, RP-8, RP-2, CN and NH2 stationary phases with dioxane — citric buffer pH 3.0 binary mobile phases containing different proportions of dioxane. RM values for pure water were extrapolated from the linear Soczewiński-Wachtmeister equation
more » ... chtmeister equation and six compounds with known literature log P values were used as reference calibration data set for computation of experimental log P values.
doi:10.2478/s11532-013-0218-3 fatcat:gqecc5jt55cdnfzqc3pr5jeq2u