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Principal network analysis: identification of subnetworks representing major dynamics using gene expression data
2010
Computer applications in the biosciences : CABIOS
Motivation: Systems biology attempts to describe complex systems behaviors in terms of dynamic operations of biological networks. However, there is lack of tools that can effectively decode complex network dynamics over multiple conditions. Results: We present principal network analysis (PNA) that can automatically capture major dynamic activation patterns over multiple conditions and then generate protein and metabolic subnetworks for the captured patterns. We first demonstrated the utility of
doi:10.1093/bioinformatics/btq670
pmid:21193522
pmcid:PMC3031040
fatcat:doczw3zryba3dlhyaxnkq3gjzq