TheBiophysicalSociety of Japan General IncorporatedAssociation gular distmbution of cell divisions which was suggested to determme shapes oforgans mtramolecularcffeLts 2sAlsoo mere"ttoitpmE7Jb-nmava)x7Acoffge,xmctr-A dynam]c model of ctll d]fferentiation to-ard understand ing of stem cell systLms Ch)kertaFurusavFa Ceraduate vehool ofi"forntanon iuenre ntnfte, iTnolosv ovaka tnt er t)) A fundamenLil preblem m stern ccll biology is hou to Lharactenze thL d]ffei ence m cellular states between

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... ferentiatLd stem cetls that hdLe potential Lo differentiate into other cell types and termmatly differentidted cel]s that cannot diffCrentaate further In this study to answcr this questien we haie camed out a dynamkal s}sterns modLlmg of mteraet]ng Lells with a gene regulatory network to revcal sLein Letl differentianon triggered by Lhe Lett cell mteractions We haye smiulated eellulan dvnamics usmg all possible 5 nude gene regulatory network topologies (more than hulldred mi]1ion) and screened regulatory networks