2012 Bipolar Disorders  
Patients with bipolar disorder (BD) or major depressive disorder (MDD) both show impaired inhibitory control. However, the brain mechanism underlying inhibitory deficit in both disorders has been incompletely described. The aim of the study is to determine the brain dysfunctions associated with inhibitory control in patients with BD or MDD using multichannel near-infrared spectroscopy (NIRS). We hypothesized that subjects would show clinically relevant alterations in changes in oxy hemoglobin
more » ... ncentration ([oxy-Hb]) in frontal lobe during the stop-signal task. Methods: Twenty-one patients with BD and 48 patients with MDD which were equally depressed were participated in the study. Changes in [oxy-Hb] concentration during the stop-signal task, a measure of motor response inhibition, were monitored using frontal probes of the 47-channel NIRS machines. Results: Both of the groups were not significantly different in the performance impairments on the stop-signal task. The BD group shows larger changes in [oxy-Hb] concentration than MDD group in bilateral middle frontal probes (p < 0.05). Changes in [oxy-Hb] concentration of the MDD group in the superior frontal probes and those of the BD group in the inferior frontal probes were correlated with the performance impairments in inhibitory control. Conclusions: Our NIRS study indicated that BD and MDD shows the different brain dysfunctions associated in the inhibitory controls.
doi:10.1111/j.1399-5618.2012.00981.x fatcat:vocgvqmcl5emrhrrwsvisung4a