Adenosine 5'-monophosphate activated protein kinase (AMPK) is a key enzymatic protein involved in linking the energy sensing to the many metabolic pathways and that has been recently shown to control male gonad and spermatozoa functions. It is indeed involved in the regulation of semen quality through its action on the proliferation of testicular somatic cells on spermatozoa motility and acrosome reaction. It also favors spermatozoa quality through the management of lipid peroxidation and

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... oxidation and antioxidant enzymes. AMPK is a heterotrimeric serine/threonine protein kinase consisting of one catalytic subunit () and two regulatory subunits ( and ) that exist as multiple isoforms and splice variants, resulting in the generation of twelve possible heterotrimeric combinations. The well-conserved genes encoding these subunits are found in the genomes of essentially all eukaryotes, including protists, fungi, plants, and animals. AMPK regulates metabolic energy balance at the whole-body level by responding to hormones and nutrient signals, which leads to changes in energy homeostasis [1] .