Survival of and hepatoma development in patients with liver cirrhosis

SHOZO NAKAMURA, YOSHIAKI TAKEZAWA, KIYOSHI KERA, TAKASHI SATO, MASA NAKAMURA, TOSHIYUKI MAEDA
1982 Tohoku journal of experimental medicine  
A follow-up study was made on 75 patients with liver cirrhosis. The patients were divided into 5 groups (discontinued alcoholic group, continued alcoholic group, hepatitis B group, male non-alcoholic non-hepatitis B group, and female non-alcoholic nonhepatitis B group). Hepatoma developed in 50% of the hepatitis B group, but in 1-9% of the other 4 groups. Abstinence did not accelerate the development of hepatoma. As for survival after onset of liver cirrhosis, the 1-4-year survival of the
more » ... non-alcoholic non-hepatitis B group and the final (8-year) survival of the hepatitis B group appeared to be lower than that of the other groups. Though the survival of the discontinued alcoholic group was seemingly higher than that of the continued alcoholic group, the difference was small and not significant. liver cirrhosis; hepatoma; survival; hepatitis B; alcoholism Recently Unuma et al. (1981) noted a high incidence of hepatoma in autopsied patients with alcoholic liver cirrhosis who had given up alcohol. Similar report was made by Lee (1966) . These views were, however, not in accord with our clinical experiences. This problem was accordingly investigated by a follow-up study of cirrhotic patients. SUBJECTS Subjects studied included 92 cirrhotic patients who had been diagnosed at the First Department of Internal Medicine, Tohoku University Hospital, or referred hospitals in 1971 to 1976. Patients who were diagnosed as having complicating hepatoma during the admission were excluded. Follow-up information was available on 75 of the 92 patients. The interval between the discharge and the follow-up study averaged 6.8 years, and that between the onset of liver cirrhosis and the study 7.9 years. The patients were etiologically divided into 5 groups : 1) discontinued alcoholic group (10 cases) who gave up drinking, 2) continued alcoholic group (23 cases) who continued drinking, 3) hepatitis B group (8 cases), 4) male non-alcoholic non-hepatitis B group (15 cases,) and 5) female non-alcoholic non-hepatitis B group (19 cases). Alcoholic cirrhosis
doi:10.1620/tjem.136.387 pmid:6285547 fatcat:f3wmprt3grf2jhjo7ot772w6oi