Urinary 45-pregnenetriol (45-pregnane-3(3, 17oc, 20a-triol) and pregnanetriol (5(3-pregnane-3a, 17cc, 20oc-triol) were measured by the previously reported gas chromatographic method in the following subjects: 26 normal adults (male 16, female 10), 5 cases with primary aldosteronism, 13 with Cush. ing's syndrome (bilateral adrenal hyperplasia 5, adrenal adenoma 4, adrenal carcinoma 4), 9 with adrenogenital syndrome (congenital adrenal hyperplasia 7, virilizing adrenal adenoma 2) and 5 cases with

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... male hypogonadism. In normal adults, mean values for urinary excretion of 45-pregnenetriol and pregnanetri. ol were 0. 15 + 0. 09 (S. D.) mg/day and 0. 29 + 0. 17 (S. D.) mg/day, respectively. These two steroids were increased by ACTH. The response of 45-pregnenetriol to ACTH suggests that there exists a biosynthetic 40