Systemic lupus erythematosus (SLE) is the prototypic multisystem autoimmune disease caused by the mistakenly in the body immune system that attacks healthy tissue in many parts of the body. Autoimmune thyroiditis (AT) is an organic-specific disease associated with production of a variety of antibodies such as antinuclear antibodies, anti-double stranded DNA, anti-Ro antibodies and anti-cardiolipin antibodies. Methods: the study consist of 90 subjects from the both sexes were registered in this

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... tudy.. The subjects have been divided in to three groups, group one and group two represent the patient groups that include, (30 SLE patients without taking steroid drugs group one (3male-27female) and 30 SLE patients with taking steroid drugs group two (2male-28female) with age range (16-57)years and thirty healthy subjects regards as a control (5male-25female)). Various clinical and laboratory parameters of SLE were measured for each groups. Also thyroid function tests were measured, which included free T3, free T4 and TSH. Antimicrosomal was measured for all groups were estimated by VIDAS method. Results : the results showed thyroid disorders were common (23.33%%) in lupus patients. Hypothyroidism was the commonest (13.33%) abnormality in SLE patients then hyperthyroidism (1.66%). At the same time, the results showed significance decreasing (p<0.01) in level of FT3 in (G1 and G2) when compared with the control group. Also, the results showed high significant decrease (p<0.01) in level of FT4 in (G2) comparison with both groups (G1) and control group. But, The results showed no significant differences (P<0.01) in level of TSH comparison with other studies groups included in the study. Further antiTPO a significant increasing (p<0.01) in (G1) comparison with both groups (G2) and control group. Then this study revealed a significance increasing of ESR, hsCRP, anti dsDNA, and ANA in both patients groups rather than control group.