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Plasma concentration monitoring of aminoglycosides
Journal of Antimicrobial Chemotherapy
A narrow therapeutic margin and poor predictability of plasma concentrations are the main reasons for drug level monitoring during aminoglycoside treatment. Gentamicin, tobramycin, amikacin and netilmicin can now be accurately and rapidly measured by radioenzymic, radio-immuno and enzyme-immuno assays. Routine determinations of peak (1-2 h post dose) and trough levels are recommended to ensure adequate dosage in all patients with serious Gram-negative infections, especially when renal functiondoi:10.1093/jac/8.suppl_a.37 pmid:7263564 fatcat:gkiyg2fo2vgspedllmrzlmk7je