Localized Myxedema, Associated with Increased Serum Hyaluronic Acid, and Response to Steroid Pulse Therapy

Yoko OHTSUKA, Kyosuke YAMAMOTO, Yumiko GOTO, Toshihiko MIZUTA, Iwata OZAKI, Yoichi SETOGUCHI, Hiromu KOHDA, Takahiro SAKAI
1995 Internal medicine (Tokyo. 1992)  
A 66-year-old man presented with Graves' disease and widespread localized myxedema. Extensive lesions were present on the legs, feet, hands, and face. TSHreceptor antibody (TBII) was markedlypositive and the serum hyaluronic acid level was very high. Intravenous steroid pulse therapy was followed by oral therapy with gradual tapering. This regimen markedly improved the skin lesions and resulted in a decrease of the serum hyaluronic acid level. The findings suggest that steroid pulse therapy is
more » ... ffective for the treatment of extensive localized myxedema.In addition, the serum hyaluronic acid level may be a useful parameter for the follow-up of patients with this condition. (Internal Medicine 34: 424-429, 1995)
doi:10.2169/internalmedicine.34.424 fatcat:qtqsrsb535e6bpwbykhnrsgn44