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Localized Myxedema, Associated with Increased Serum Hyaluronic Acid, and Response to Steroid Pulse Therapy
Internal medicine (Tokyo. 1992)
A 66-year-old man presented with Graves' disease and widespread localized myxedema. Extensive lesions were present on the legs, feet, hands, and face. TSHreceptor antibody (TBII) was markedlypositive and the serum hyaluronic acid level was very high. Intravenous steroid pulse therapy was followed by oral therapy with gradual tapering. This regimen markedly improved the skin lesions and resulted in a decrease of the serum hyaluronic acid level. The findings suggest that steroid pulse therapy isdoi:10.2169/internalmedicine.34.424 fatcat:qtqsrsb535e6bpwbykhnrsgn44