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Analyse von Hodgkin-Zellen in B-Zell chronischer lymphatischer Leukämie mittels Einzelzell-PCR und Untersuchungen zur Etablierung der Einzelzell-PCR von Zellen aus Formalin-fixierten, in Paraffin eingebetteten Biopsaten
The occurence of HRS cells in cases of human CLL is a rare phenomenon. Until recently, investigations on the origin of these HRS cells were restricted on morphological description and immunohistochemical analysis. In this thesis, the first molecular analysia of Ig gene rearrangements of a case of B-CLL with HRS cells on the level of individual cells by single cell PCR is presented. The analysis aimed at a more detailed understanding of the possible relationship between Hodgkin´s disease anddoi:10.17169/refubium-10157 fatcat:5rzbesehzfeltdon7nz24nfwn4