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A Molecular Logic of Sensory Coding Revealed by Optical Tagging of Physiologically-Defined Neuronal Types
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Neural circuit analysis relies on having molecular markers for specific cell types. However, for a cell type identified only by its circuit function, the process of identifying markers remains laborious. Here, we report photoactivated intersectional physiology sequencing (PIPseq), a technique for tagging and expression-profiling cells based on their functional properties. We demonstrate that PIPseq is capable of selecting rare cell types and enriching them by nearly one hundred-fold. We applied
doi:10.7936/w2c7-vw75
fatcat:zhnvgrra55alxkjliwkuesomqa