GPOPSIM: a simulation tool for whole-genome genetic data

Zhe Zhang, Xiujin Li, Xiangdong Ding, Jiaqi Li, Qin Zhang
2015 BMC Genetics  
Population-wide genotypic and phenotypic data is frequently used to predict the disease risk or genetic/phenotypic values, or to localize genetic variations responsible for complex traits. GPOPSIM is a simulation tool for pedigree, phenotypes, and genomic data, with a variety of population and genome structures and trait genetic architectures. It provides flexible parameter settings for a wide discipline of users, especially can simulate multiple genetically correlated traits with desired
more » ... c parameters and underlying genetic architectures. Results: The model implemented in GPOPSIM is presented, and the code has been made freely available to the community. Data simulated by GPOPSIM is a good mimic to the real data in terms of genome structure and trait underlying genetic architecture. Conclusions: GPOPSIM would be a useful tool for the methodological and theoretical studies in the population and quantitative genetics and breeding.
doi:10.1186/s12863-015-0173-4 pmid:25652552 pmcid:PMC4328615 fatcat:hbjdkkhxsze2vjutps5qoznbl4