The Effect Of Estrogen On The Male Reproductive System Of Rats Receiving Cimetidine

Ali Hammodi, Sajeda Al-Chalabi, Rana A. Asem
1999 Journal of education and science  
‫الخالصة‬ ‫اسة‬ ‫الدر‬ ‫هذه‬ ‫في‬ ‫استخدم‬ 25 ‫االستروجين‬ ‫استعمال‬ ‫تداخل‬ ‫مدى‬ ‫اسة‬ ‫لدر‬ ‫سوي‬ ‫بالغ‬ ‫ذكر‬ ‫جرذ‬ ‫الذكري‬ ‫التناسمي‬ ‫الجهاز‬ ‫فعالية‬ ‫عمى‬ ‫بالسيميتدين‬ ‫البالغة‬ ‫الجرذان‬ ‫معاممة‬ ‫تأثير‬ ‫في‬ ‫قميمة‬ ‫بجرعة‬ . ‫المعاممة‬ ‫مجموعة‬ ‫و‬ ‫ة‬ ‫السيطر‬ ‫مجموعة‬ ‫تضمنت‬ ‫مجاميع‬ ‫خمس‬ ‫الى‬ ‫ائيا‬ ‫عشو‬ ‫انات‬ ‫الحيو‬ ‫قسمت‬ G1 ‫جرعة‬ ‫السيمتيدين‬ ‫أعطيت‬ ‫التي‬ 50 ‫ممغم‬ \ ‫كغم‬ ‫من‬ ‫األنبوب‬ ‫اسطة‬ ‫بو‬ ‫الفم‬ ‫يق‬ ‫طر‬ ‫عن‬ ‫الجسم‬ ‫وزن‬ ‫المعدي‬ ‫ل‬ ‫مدة‬ 60 ‫بجرعة‬
more » ... ‫مدة‬ 60 ‫بجرعة‬ ‫ادايول‬ ‫االسر‬ ‫حقنت‬ ‫و‬ ‫يوم‬ 0.01 µg ‫الجمد‬ ‫تحت‬ ‫ل‬ ‫مدة‬ 10 ‫متتالية‬ ‫أيام‬ ‫المعاممة‬ ‫مجموعة‬ ‫و‬ ‫بة‬ ‫لمتجر‬ ‫األول‬ ‫اليوم‬ ‫من‬ G2 ‫جرعة‬ ‫السيمتيدين‬ ‫أعطيت‬ ‫التي‬ 50 ‫ممغم‬ \ ‫كغم‬ ‫الجس‬ ‫وزن‬ ‫بجرعة‬ ‫ادايول‬ ‫االسر‬ ‫وحقنت‬ ‫الفم‬ ‫يق‬ ‫طر‬ ‫عن‬ ‫م‬ 0.01 µg ‫مدة‬ ‫الجمد‬ ‫تحت‬ 10 ‫أيام‬ ‫اليوم‬ ‫من‬ ‫متتالية‬ 20 -30 ‫المعاممة‬ ‫مجموعة‬ ‫و‬ ‫بة‬ ‫التجر‬ ‫من‬ G3 ‫جرعة‬ ‫السيمتيدين‬ ‫أعطيت‬ ‫التي‬ 50 ‫ممغم‬ \ ‫بجرعة‬ ‫ادايول‬ ‫االسر‬ ‫وحقنت‬ ‫الفم‬ ‫يق‬ ‫طر‬ ‫عن‬ ‫الجسم‬ ‫وزن‬ ‫كغم‬ 0.01 µg ‫مدة‬ ‫الجمد‬ ‫تحت‬ 10 ‫الي‬ ‫من‬ ‫متتالية‬ ‫أيام‬ ‫وم‬ 40 -50 ‫المعاممة‬ ‫مجموعة‬ ‫و‬ G4 ‫جرعة‬ ‫السيمتيدين‬ ‫أعطيت‬ ‫التي‬ 50 ‫ممغم‬ \ ‫بجرعة‬ ‫ادايول‬ ‫االسر‬ ‫وحقنت‬ ‫الفم‬ ‫يق‬ ‫طر‬ ‫عن‬ ‫الجسم‬ ‫وزن‬ ‫كغم‬ 0.01 µg ‫مدة‬ ‫الجمد‬ ‫تحت‬ 10 ‫اليوم‬ ‫من‬ ‫متتالية‬ ‫أيام‬ 50 -60 , ‫بعد‬ ‫و‬ ‫قبل‬ ‫الجرذان‬ ‫وزن‬ ‫اخذ‬ ‫تم‬ ‫انتهاء‬ ‫بة‬ ‫التجر‬ . ‫تم‬ ‫قتل‬ ‫اليوم‬ ‫في‬ ‫انات‬ ‫الحيو‬ 61 , ‫حيث‬ ‫س‬ ‫تم‬ ‫الدم‬ ‫حب‬ ‫ة‬ ‫مباشر‬ ‫بقميل‬ ‫القتل‬ ‫قبل‬ ‫أنبوب‬ ‫اسطة‬ ‫بو‬ ‫العين‬ ‫من‬ ‫و‬ ‫التستوستيرون‬ ‫هرمون‬ ‫مستوى‬ ‫لقياس‬ ‫شعري‬ FSH ‫المصل‬ ‫في‬ . ‫األعضاء‬ ‫ان‬ ‫أوز‬ ‫حساب‬ ‫تم‬ ‫كذلك‬ ‫بخ‬ ‫البر‬ ‫و‬ ‫الخصى‬ ‫وهي‬ ‫التناسمية‬ ( ‫الذيل‬ ‫و‬ ‫الجسم‬ ‫و‬ ‫أس‬ ‫الر‬ ) ‫البروستات‬ ‫و‬ ‫المنوية‬ ‫الحويصمة‬ ‫و‬ . ‫تم‬ ‫المئوية‬ ‫النسبة‬ ‫و‬ ‫الكمي‬ ‫النطف‬ ‫عدد‬ ‫حساب‬ ‫الميتة‬ ‫و‬ ‫الحية‬ ‫النطف‬ . ‫من‬ ‫كل‬ ‫وزن‬ ‫في‬ ‫يادة‬ ‫ز‬ ‫لوحظ‬ ‫في‬ ‫المنوية‬ ‫الحويصمة‬ ‫وزن‬ ‫نقصان‬ ‫مع‬ ‫البروستات‬ ‫و‬ ‫الخصى‬ ‫ال‬ ‫المعاممة‬ ‫مجاميع‬ G3, G4 ‫نة‬ ‫مقار‬ The Effect Of Estrogen On The Male Reproductive System Of Rats ... 99 ‫ة‬ ‫السيطر‬ ‫بمجموعة‬ . ‫كما‬ ‫هرمون‬ ‫مستوى‬ ‫في‬ ‫يادة‬ ‫ز‬ ‫لوحظ‬ FSH ‫حين‬ ‫في‬ ‫ة‬ ‫السيطر‬ ‫بمجموعة‬ ‫نة‬ ‫مقار‬ ‫طيل‬ ‫التستوستيرون‬ ‫مستوى‬ ‫يتغير‬ ‫لم‬ ‫ة‬ ‫في‬ ‫بة‬ ‫التجر‬ ‫ة‬ ‫فتر‬ ‫كافة‬ ‫ال‬ ‫مجاميع‬ . ‫حدث‬ ‫انخفاض‬ ‫عدد‬ ‫في‬ ‫نة‬ ‫مقار‬ ‫الميتة‬ ‫لمنطف‬ ‫المئوية‬ ‫النسبة‬ ‫في‬ ‫يادة‬ ‫ز‬ ‫و‬ ‫الحية‬ ‫لمنطف‬ ‫المئوية‬ ‫النسبة‬ ‫و‬ ‫الكمية‬ ‫النطف‬ ‫ة‬ ‫السيطر‬ ‫بمجموعة‬ . ‫أذى‬ ‫إحداث‬ ‫الى‬ ‫السيمتيدين‬ ‫أدى‬ ‫تثبيط‬ ‫و‬ ‫يتداخل‬ ‫ولم‬ ‫الذكري‬ ‫التناسمي‬ ‫لمجهاز‬ ‫الضار‬ ‫التأثير‬ ‫هذا‬ ‫عكس‬ ‫في‬ ‫االستروجين‬ . Abstract To show if a small dose of estrogen can interfere with the effect of Cimetidine on male reproductive system. Five groups of five randomly selected adult male rats were utilized. Rats were given food (laboratory rat chow) and water ad libitum. Rats were treated orally with Cimetidine 50mg/kg and subcutaneous injection with estradiol 0.01µg for 60 days. The animals were grouped as: group1, treated from days 1-10. Group2, treated from days 20-30. Group3, treated from days 40-50. Group4, treated from days 50-60. Group 5 received no treatment as a control group. Blood samples were taken from the eyes (by using capillary tubes) to measure testosterone (T) and follicular stimulating hormone (FSH) levels. Measurement of weights of the reproductive organs including the testis, epididymis (head, body, and tail), seminal vesicle and prostate were done. Body weight for each animal was recorded before and after treatment. Also we counted the total sperm count and the percentage of dead and alive spermatozoa for the treated groups using Eosin-negrosin stain. The testis weight and prostate weight was significantly increased in both groups 3 and 4, while seminal vesicle weight was significantly reduced. FSH levels were significantly increased, while testosterone levels were unchanged. Total sperm count and a number of a live sperms were significantly reduced and the number of dead sperms was significantly increased among the treated groups. Cimetidine has hazards on male reproductive function while estrogen didn't play any role to abolish this action.
doi:10.33899/edusj.1999.58794 fatcat:kczy3eqvpzhynjjnrktg7epqci