A generalized additive model to disentangle age and diagnosis-specific cohort effects in psychological and behavioral outcomes in people living with HIV: the French cross-sectional ANRS-VESPA2 survey

Luis Sagaon-Teyssier, Antoine Vilotitch, Marion Mora, Gwenaëlle Maradan, Valérie Guagliardo, Marie Suzan-Monti, Rosemary Dray-Spira, Bruno Spire
2019 BMC Public Health  
Unlike their younger counterparts, some of today's older HIV patients were diagnosed before the advent of highly active antiretroviral therapy (HAART). The psychosocial and behavioral outcomes of people living with HIV (PLWH) have been widely studied, and associated factors are well known. However, their evolution both in terms of age and diagnosis-specific cohort effects is not well understood. Methods: Data from the ANRS-VESPA2 cross-sectional survey, representative of French PLWH, were used
more » ... o investigate whether psychosocial and behavioral outcomes such as quality of life, need for support and HIV status disclosure, evolve under both the influence of patients' age and diagnosis-specific cohort effects. A semi-parametric generalized additive model (GAM) was employed. The physical and mental components of health-related quality of life, the need for material and moral support, and HIV-status disclosure, constituted our outcomes.
doi:10.1186/s12889-019-6905-z fatcat:eiisd6x6pvckpiphbfrhcea6nq