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Direct comparison of human diseases with model phenotypes allows exploration of key areas of human biology which are often inaccessible for practical or ethical reasons. We review recent developments in comparative evolutionary approaches for finding models for genetic disease, including high-throughput generation of gene/phenotype relationship data, the linking of orthologous genes and phenotypes across species, and statistical methods for linking human diseases to model phenotypes.doi:10.1016/j.gde.2015.08.004 pmid:26338499 pmcid:PMC4947381 fatcat:xcgt5oe6pvga5jemouyxho6pzq