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The stilbene and dibenzo[b,f]oxepine derivatives as anticancer compounds
2020
Biomedicine and Pharmacotherapy
In the present study, the synthesis and cytotoxic effect of six stilbenes and three oxepine derivatives against two cancerous - HeLa and U87, and two normal - EUFA30 and HEK293 cell lines has been reported. The results of cytotoxic assay and flow cytometry analysis revealed that compounds 9-nitrobenzo[b]naphtho[1,2-f]oxepine (4), (E)-3,3',4,4',5,5'-hexamethoxystilbene (6) and 4-hydroxy-2',4'-dinitrostilbene (8) were the most active and their interaction with tubulin (crystal structure from PDB)
doi:10.1016/j.biopha.2019.109781
pmid:31865147
fatcat:5g5j5tvfpjajxmrp3mn3c6enki