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Animal models and cell cultures have contributed new knowledge in biological sciences, including Periodontology. Although cultured cells can be used to study physiological processes that occur during the pathogenesis of periodontitis, the complex host response fundamentally responsible for this disease cannot be reproduced in vitro. Among the animal kingdom, rodents, rabbits, pigs, dogs, and nonhuman primates have been used to model human periodontitis, each with advantages and disadvantages.doi:10.5866/2015.7.10268 fatcat:n3673awvobgmjhbbsasa2zgkyi