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Local and substrate-specific S-palmitoylation determines subcellular localization of Gαo
Peripheral membrane proteins (PMPs) associate with cellular membranes through post-translational modifications like S-palmitoylation. The Golgi apparatus is generally viewed as the transitory station where palmitoyl acyltransferases (PATs) modify PMPs, which are then transported to their ultimate destinations such as plasma membrane (PM); little substrate specificity among the many PATs has been determined. Here we describe inherent partitioning of Gαo - α-subunit of heterotrimeric Go-proteinsdoi:10.1101/2020.08.25.266692 fatcat:dbizlel2kvfd7h56mzobdxu6qy