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pH-mediated molecular differentiation for fluorimetric quantification of chemotherapeutic drugs in human plasma
[post]
2017
unpublished
Preserved Fulltext
At present, drug dosage is based on standardised approaches that disregard pharmakokinetic differences between patients and lead to non-optimal efficacy and unnecessary side effects. In this work, we demonstrate the potential of pH-mediated fluorescence spectroscopy for therapeutic drug monitoring in complex media. We apply this principle to the simultaneous quantification of the chemotherapeutic prodrug Irinotecan and its active metabolite SN-38 from human plasma across the clinically relevant
doi:10.26434/chemrxiv.5662462.v1
fatcat:k2uosnlncrc43eyc3err57kdpy