Quantitative modeling of fine-scale variations in the Arabidopsis thaliana crossover landscape [article]

Yu-Ming Hsu, Matthieu Falque, Olivier C. Martin
2021 bioRxiv   pre-print
AbstractIn essentially all species where meiotic crossovers have been studied, they occur preferentially in open chromatin, typically near gene promoters and to a lesser extent at the end of genes. Here, in the case of Arabidopsis thaliana, we unveil further trends arising when one considers contextual information, namely summarized epigenetic status, size of underlying genomic regions and degree of divergence between homologs. For instance we find that intergenic recombination rate is reduced
more » ... f those regions are less than 1.5 kb in size. Furthermore, we propose that the presence of single nucleotide polymorphisms is a factor driving enhanced crossover rate compared to when homologous sequences are identical, in agreement with previous works comparing rates in homozygous and heterozygous blocks. Lastly, by integrating these different factors, we produce a quantitative and predictive model of the recombination landscape that reproduces much of the experimental variation.
doi:10.1101/2021.10.06.463263 fatcat:bz2gocusyzgjjg7ma3aojoha34