The failure of allopurinol to enhance 6-mercaptopurine toxicity in rabbits

R I Walker, W L Horvath, W S Rule, J C Herion, J G Palmer
1973 Cancer Research  
We have evaluated the effect of allopurinol on the hematopoietic toxicity of 6-mercaptopurine in rabbits by studying the development of neutropenia in animals that received only 6-mercaptopurine and in those that received both drugs. The studies showed that, rather than demonstrat ing any potentiation of 6-mercaptopurine toxicity, allopurinol protected the animals, as evidenced by less weight loss, less depression of neutrophils, and lower mortality.
pmid:4696475 fatcat:vlcf2q2iwzgszdtyntpgh4pd5m