Primary drug resistance to anti-tuberculous drugs in Karachi

Arshad Javaid, Nadim Rizvi, Mosavir Ansari, Ashraf Sadiq, Iqbal Sher Burki, Nadeem Ur Rehman, Rumina Hasan, Afia Zafar
2008 Journal of the College of Physicians and Surgeons  
To assess the frequency of primary drug resistance among newly diagnosed tuberculosis cases in Karachi. Cross-sectional study. Multicentric study involving various TB clinics and treatment centres of Karachi between April to December 2005. The frequency of drug resistance among new TB patients was evaluated using a non-probability convenient sampling methodology. Sputum sample was obtained from 140 newly diagnosed sputum smear-positive patients of pulmonary tuberculosis from various centres of
more » ... arachi. Sensitivities were performed by proportion method. Fifteen (11.5%) samples in 130 eligible patients showed primary resistance to one or more drugs. Ten (7.6%) of the isolates tested were resistant to a single drug, none were resistant to 2 drugs, 4 (3.0%) to 3 drugs and 1 (0.76%) to 4 drugs while 1 (0.76%) to all 5 first line agents. Resistance to streptomycin (10 microg/ml) was seen in 8 (6.1%), isoniazid (1microg/ml) in 12 (9.2%), Rifampicin (5 microg/ml) in 4 (3.0%), ethambutol (10 microg/ml) in 1 (0.76%) and pyrazinamide in 6 (4.6%) samples. Primary Multi-Drug Resistance (PMDR) was found in 2 (1.5%) patients. (Isoniazid 1 microg/ml, rifampicin 5 microg/ml with or without other drugs). In the studied patients, primary drug resistance to at least one anti-tuberculosis drug was 11.5%. It requires an efficiently working anti-tuberculosis programme to prevent escalation including resistance.
pmid:18983794 fatcat:psbn7i3kyjg4zdl6ml4lyvkd7y