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The effect of the branched-chain amino acids on the in-vitro activity of bovine intestinal alkaline phosphatase
2018
Applied Physiology, Nutrition and Metabolism
Branched-chain amino acids (BCAA) are used as nutritional support for patients with a range of conditions including liver cirrhosis and in-born errors of amino acid metabolism, and are commonly used "sports"/exercise supplements. The effects of the BCAA on the in-vitro activity of calf intestinal alkaline phosphatase (EC. 3.1.3.1) were studied. All three BCAA were found to be uncompetitive inhibitors of the enzyme with L-leucine being the most potent (Ki ' = 24.9mM) and L-valine, the least
doi:10.1139/apnm-2018-0449
pmid:30398915
fatcat:c4whsqsbazeghiqoptdtvisrlq