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Background: Human infections by rat HEV (HEV-C1) have been serially reported, including a case who had visited Taiwan before having the illness in 2019. The objective of this study was to investigate whether HEV-C1 is circulating and causing human infections in Taiwan.Methods: Fifty acute-phase human sera samples from HEV suspected patients with the negative results were randomly chosen for retrospective review. Rat sera were collected from 3 Rattus rattus and 47 R. norvegicus, which weredoi:10.21203/rs.3.rs-41240/v1 fatcat:i2oc27cwvzgyzc2dokwoczw7qa