Synthesis, X-ray analysis and antibacterial study of silver complex with ethyl-5-hydroxy- 2-oxo-2H-chromene-3-carboxylate

H. Rehman, Z. Ali, T. G. Shahzady, M. A. Abid, S. Nazir, H. Hussain, A. Zahra, I. Hussain
2019 Bulletin of the Chemical Society of Ethiopia  
A novel silver complex [Ag(C12H9O5)2] was synthesized by the reaction of silver salt (AgNO3) and coumarin based ligand (ethyl-5-hydroxy-2-oxo-2H-Chromene-3-carboxylate) at room temperature. The synthesized complex was characterized by using different analytical techniques like melting point (mp), infrared (IR) spectroscopy, powder X-ray diffraction (PXRD), thermo gravimetric analysis (TGA), atomic absorption spectroscopy (AAS) and mass spectrometry (ESI-MS). Ligand showed activity with MIC 20
more » ... ivity with MIC 20 µg/mL, 15 µg/mL, 15 µg/mL for S. aurues, E. coli and S. typhi, respectively whereas MIC values of Ag-complex for above mentioned bacterial strains were found to be 15 µg/mL, 10 µg/mL, 10 µg/mL, respectively. Ligand could not inhibit the growth of B. Subtilis, P. auruginosa, MRSA but Ag-complex showed MIC 30 µg/mL, 25 µg/mL for B. Subtilis and P. auruginosa. It also remained ineffective against MRSA.
doi:10.4314/bcse.v33i3.7 fatcat:rs6bldakdrblfjuphbcpqdp2du