Objective To evaluate the comprehensive nursing program based on Delphi method for patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods Totally 106 patients with AECOPD were randomly divided into control group (n=48, 5 cases were lost to follow up) and intervention group (n=47, 6 cases were lost to follow up). The control group was given routine nursing before discharge from hospital, and the intervention group was given comprehensive nursing interventions

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... ased on Delphi method. The readmission rate, quality of life and self-management ability of the two groups were compared one month and six months after discharge from hospital. The rate of readmission between the two groups one and six months after discharge from hospital was compared. The quality of life, 6-minute Walk Test (6MWT) and self-management ability of patients were evaluated before and after intervention. Results There was no significant difference in the rate of readmission between the two groups one month after intervention (P>0. 05), and the rate of readmission in the intervention group after six months was significantly lower than that of the control group(P<0. 05). The St George's Respiratory Questionnaire (SGRQ) score, respiratory symptoms, activity restriction and disease influence were significantly lower than those in the control group (P<0. 05), and the self-management ability and 6MWT were significantly higher than that of the control group (P<0. 05). Conclusion The comprehensive nursing programe based on Delphi method can significantly reduce the rate of readmission of patients with AECOPD , improve their quality of life and improve their self-management ability.