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Upregulation of Placental Indoleamine 2,3-Dioxygenase by Human Chorionic Gonadotropin
2007
Biology of Reproduction
We tested the hypothesis that hCG can upregulate human trophoblast indoleamine 2, 3-dioxygenase (INDO), which catalyzes the breakdown of tryptophan in villous circulation. The results revealed that it can. Treatment of human trophoblasts with hCG resulted in a time and dose dependent increase in INDO mRNA and protein levels and its enzyme activity. The hCG effect was hormone specific and required the dimer conformation of hCG. The hCG effect required its receptors and was mediated by a cAMP
doi:10.1095/biolreprod.106.056960
pmid:17182891
fatcat:u67gjwum3jdpxcepjce7kexdai