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Identification, crystallization and epitope determination of public TCR shared and expanded in COVID-19 patients
T cells play pivotal roles in protective immunity against SARS-CoV-2 infection. Follicular helper T (Tfh) cells mediate the production of antigen-specific antibodies; however, T cell receptor (TCR) clonotypes used by SARS-CoV-2-specific Tfh cells have not been well characterized. Here, we first identified and crystallized public TCR of Tfh clonotypes that are shared and expanded in unhospitalized COVID-19-recovered patients. These clonotypes preferentially recognized SARS-CoV-2 spike (S)doi:10.1101/2021.03.23.436573 fatcat:kvd7wyiifrgylm6aebrvpywxfi