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Landscape of X chromosome inactivation across human tissues
[article]
2016
bioRxiv
pre-print
X chromosome inactivation (XCI) silences the transcription from one of the two X chromosomes in mammalian female cells to balance expression dosage between XX females and XY males. XCI is, however, characteristically incomplete in humans: up to one third of X-chromosomal genes are expressed from both the active and inactive X chromosomes (Xa and Xi, respectively) in female cells, with the degree of "escape" from inactivation varying between genes and individuals1,2(Fig. 1). However, the extent
doi:10.1101/073957
fatcat:qjkfoeuwhjgvhcxnkwjjxru2ri