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Nucleotide Dynamics During Flossing of Polycation-DNA-Polycation through a Nanopore using Molecular Dynamics
[article]
2021
bioRxiv
pre-print
The full potential of solid state nanopores is yet to be realized for genome sequencing. Due to its robustness it can handle strong voltage amplitude and frequency. The effect of strong alternating voltage on the dynamics of nucleotides during translocation has been explored. We proposed a setup consisting of single stranded DNA covalently linked with symmetric polycations at both ends fashioned after the proposal of Kasianowicz. Such a setup allows for repeated back and forth motion of the DNA
doi:10.1101/2021.06.21.449276
fatcat:vofam2b7m5b2bmt46ei5eax3mq