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Protein interaction prediction for mouse pdz domains using dipeptide composition features
2011
2011 IEEE International Conference on Systems Biology (ISB)
The PDZ domain is one of the largest families of protein domains that are involved in targeting and routing specific proteins in signaling pathways. PDZ domains mediate protein-protein interactions by binding the C-terminal peptides of their target proteins. Using the dipeptide feature encoding, we develop a PDZ domain interaction predictor using a support vector machine that achieves a high accuracy rate of 82.49%. Since most of the dipeptide compositions are redundant and irrelevant, we
doi:10.1109/isb.2011.6033143
fatcat:rgu26wnnqbg53nwy5wjo6ao27y