pH-dependent ileocolonic drug delivery, part I: in vitro and clinical evaluation of novel systems

Annemarie Broesder, H.J. Woerdenbag, G.G.H. Prins, D.N. Nguyen, Hendrich W. Frijlink, Wouter L.J. Hinrichs
2020 Drug Discovery Today  
pH-dependent ileocolonic drug delivery systems rely on the sharp pH peak reaching 7.2-7.7 usually found in the ileum of healthy individuals and patients with colonic diseases. The pH dependency of novel drug delivery systems should first be evaluated in in vitro dissolution tests mimicking the human gastrointestinal (GI) pH profile and buffer composition. When proven successful in vitro, the clinical applicability of a novel system should be confirmed in humans. Various methods have been
more » ... ds have been published to verify ileocolonic drug delivery in humans. Of those, we recommend the caffeine-sulfasalazine method and the dual stable isotope approach.
doi:10.1016/j.drudis.2020.06.011 pmid:32554060 fatcat:yi2pg7kcmje57mdaszqfxydgbe