Recombinant Human Bone Morphogenic Protein-2 (BMP-2): A Newer & Novel Osteoinductive Treatment Modality for Non-union of Bones

Vinod Agrawal, Saurav Narayan Nanda, Sanjay Tripathi, Munjal Satish Shah, Karmesh Lakhani, Aniruddha Agrawal, Himanshu Parmar
2016 Annals of International medical and Dental Research  
The non-union of bones is a multifactorial phenomenon. In this study, it was emphasized to evaluate the efficacy and safety of bone morphogenetic protein-2 (BMP-2) as a bone-stimulating agent in the treatment of non-unions. Methods: Fifteen patients [5 males, mean age 51.06 years (range: 21-75)] with sixteen non-unions were treated with BMP-2. There were eleven femoral non-union, three humerus, one ulna, one distal fibula non-union. The mean follow-up was 22.06 months. Results: Both clinical
more » ... radiological union occurred in 15 (93.75%) non unions cases. Radiological union achieved within a mean time of 15.75 weeks. The remaining one show incomplete union with recalcitrant formation was asymptomatic and having good pain free range of movement, declines further intervention. No complications or adverse effects from the use of BMP-2 were encountered. Conclusion: In this study, it was observed that BMP-2 is a powerful adjunct and one of the safe armamentarium for the surgeon to handle difficult and challenging clinical conditions.
doi:10.21276/aimdr.2016.2.5.or9 fatcat:rimjwajeeff5beo6vaei2dnuem