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Is interleukin-1α a luteotrophic or luteolytic agent in cattle?
Cytokines are thought to regulate prostaglandin (PG) secretion in the bovine endometrium. However, there is no consensus about the role of interleukin-1α (IL1A) on PG secretion. The objective of this study was to examine the influence of IL1A on basal and interferon-τ (IFNT)-regulated PG in vitro secretion, as well its effects on PG secretion, progesterone (P4) output, and corpus luteum (CL) in vivo lifespan. Explants of bovine endometrium (days 16–17 of the estrous cycle or early pregnancy)doi:10.1530/rep-09-0328 pmid:20032213 fatcat:lloq6u3txbaa3hqgzdcn2gxnua