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Infectivity and Capacity for DNA Replication of Vaccinia Virus Irradiated by -Rays
Journal of General Virology
Purified vaccinia virus was irradiated by 7-rays under direct-effect conditions. The ability of the irradiated samples to form plaques (infectivity) and to induce viral DNA synthesis was determined. The radiosensitive volume of the viral unit causing infection (I.9 × IO-X7 cm2) is very small compared with the volume of the whole viral DNA (~ IO %). The inactivation of the D N A replication function follows a simple exponential law. The radiosensitive volume necessary for the replication of DNAdoi:10.1099/0022-1317-4-2-221 pmid:5772488 fatcat:p4tr7xeicneybeg6afyn6fjfii