Secondary metabolites from cultures of the ant pathogenic fungus Ophiocordyceps irangiensis BCC 2728

Siriporn Saepua, Jittra Kornsakulkarn, Patchanee Auncharoen, Pranee Rachtawee, Surisa Kongthong, Nattawut Boonyuen, David J. Harding, Tatsuo Nehira, Tienthong Thongpanchang, Chawanee Thongpanchang
2020 Figshare  
Five new compounds, iranginins A–E (1–5), together with sixteen known compounds were isolated from the insect pathogenic fungus Ophiocordyceps irangiensis BCC 2728. The structures and the absolute configurations of the new compounds were established by spectroscopic analyses, the application of modified Mosher's method (for 2), ECD calculation (for 5), and X-ray crystallographic analysis (for 4). LL-Z1640-5 and mucorisocoumarin C were active against Mycobacterium tuberculosis (MIC 41.7 and 85.0
more » ... (MIC 41.7 and 85.0 µM, respectively), while peyroisocoumarin D exhibited cytotoxic activity (IC50 65.6 µM).
doi:10.6084/m9.figshare.11604021.v1 fatcat:smiquceg45alrmkkhxvvjvfyji