The purpose of my study is to prospectively assess the diagnostic performance of 128-slice Multidetector computed tomography (CT) for coronary artery disease with conventional coronary angiography as reference standard Methods: 128 slice CT coronary angiography was performed in 53 patients prior to conventional coronary angiography. 7 patients had prior surgical intervention. Results: On CT coronary angiography, out of 46 patients -16 (normal), 10 (insignificant stenosis), 11(Single vessel

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... se), 5 (Two vessel disease) & 4 (three vessel disease). Out of the total 53 lesions detected in DSA 14 (mild grade), 22(moderate grade) & 17 (severe grade). Conclusion: 128 slice MDCT is currently the most accurate & non-invasive modality for the detection of coronary artery disease. However in the future, it will not replace coronary angiography as the reference tool. In patients with modest heart rate MDCT is a reliable alternative to catheter angiography.