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IET Systems Biology
Axon guidance by graded diffusible ligands plays an important role in the developing nervous system. Concentration gradients induce an asymmetric localization of molecules in the axon tip, the growth cone, and the consequent internal polarized signaling pathway leads to rearrangement of the growth cone cytoskeleton and, ultimately, to motility. In this work, we provide a mathematical description of the growth cone transduction chain as a series of functional boxes characterized by input/outputdoi:10.1049/iet-syb:20070059 pmid:18537455 fatcat:3u6scxkgxjhpfmgz24j5ju2y4y