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Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila
The discovery of human obesity-associated genes can reveal new mechanisms to target for weight loss therapy. Genetic studies of obese individuals and the analysis of rare genetic variants can identify novel obesity-associated genes. However, establishing a functional relationship between these candidate genes and adiposity remains a significant challenge. We uncovered a large number of rare homozygous gene variants by exome sequencing of severely obese children, including those fromdoi:10.17863/cam.77900 fatcat:zulvfc54kra4ddzjpyxdsib6ci