Short-Term Catheter-Directed Thrombolysis with Low-Dose Urokinase Followed by Aspiration Thrombectomy for Treatment of Symptomatic Lower Extremity Deep Venous Thrombosis

Se Hee Jung, Jae Kyu Kim, Nam Kyu Chang, Jae Hoon Lim, Nam-Yeul Lim, Jang-Hyeon Song, Soo Jin Na Choi, Sang Young Chung
2011 Journal of the Korean Society of Radiology  
submit.radiology.or.kr J Korean Soc Radiol 2011;65(4):337-344 thrombolysis. Among them, catheter-directed thrombolysis is an attractive method, because it can potentially help achieve restoration of the lumen and removal of the thrombus lining Purpose: To evaluate the venous patency in patients treated by catheter-directed thrombolysis with low-dose urokinase (UK) for symptomatic lower extremity deep venous thrombosis (DVT). Materials and Methods: Eighty-nine consecutive patients (46 women and
more » ... 3 men; mean age, 58.1 years), treated by catheter-directed thrombolysis with lowdose UK were included in this study. Immediate venous patency was evaluated in terms of technical success (successful restoration of antegrade in-line flow in the treated vein with residual stenosis rate of less than 30%) and clinical success (significant reduction of clinical symptoms before hospital discharge). Late venous patency was evaluated in terms of primary patency rate and clinical success. Results: Immediate technical success was achieved in all patients and immediate clinical success in 80 (90%) patients. There was no major systemic bleeding complication. The primary patency rate at 6 months and 12 months was 84% and 79%, respectively. Fifty-six (63%) patients were asymptomatic after a median clinical follow-up of 18 months, eleven (12%) patients improved moderately, seven (8%) patients remained unchanged, and fifteen (17%) patients had no clinical follow-up. Conclusion: Short-term catheter-directed thrombolysis with low-dose UK can be an effective, safe method to manage DVT of the lower extremities. Short-Term Catheter-Directed Thrombolysis with UK Followed by Aspiration Thrombectomy for Treatment of Lower Extremity DVT submit.radiology.or.kr J Korean Soc Radiol 2011;65(4):337-344 Note.-VCTA = venous computed tomography angiography Short-Term Catheter-Directed Thrombolysis with UK Followed by Aspiration Thrombectomy for Treatment of Lower Extremity DVT submit.radiology.or.kr J Korean Soc Radiol 2011;65(4):337-344
doi:10.3348/jksr.2011.65.4.337 fatcat:s3v4bs6rubdvrd42ja77f6oqj4