Synthesis of Dimeric Acridine Derived Nucleic Acid Intercalators

René Csuk, Thorsten Brezesinski, Gunnar Göthe, Christian Raschke, Stefan Reißmann
2005 Zeitschrift für Naturforschung. B, A journal of chemical sciences  
A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA-derived conjugate was synthesized in an easy sequence. Suitably monoprotected 1,ω-alkyldiamines gave upon reaction with 6,9-dichloro-2-methoxyacridine (1) followed by deprotection and reaction with EDTA dianhydride the target molecules. In the presence of ascorbate a reduction of the phage-titer of the MS2 phages by > 8 logarithmic decades was achieved.
doi:10.1515/znb-2005-0114 fatcat:h4t3h2dw2vednbttd4jpr7kj7e