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Urbanization has been implicated as having an important influence on brain development and risk for psychiatric disorders but the mechanisms in brain and the role of genetic background have been unresolved. Here we explored major urbanization changes in recent history in China, and its correlates with brain structure and function in a genetically controlled sample with similar current education and socioeconomic status. Principal component analyses showed no global genomic differences acrossdoi:10.1101/246876 fatcat:e5a5lf5hyrahxe2hugnr22pdh4