A STUDY OF VARIOUS DRUGS CAUSING FIXED DRUG ERUPTIONS
English

Kamala Kuna, Jhansi Rani M, Shirisha N, Sudha J
2015 Journal of Evolution of Medical and Dental Sciences  
AIM: To study the pattern of fixed drug eruptions to various drugs and to find out the common drugs causing fixed drug eruptions using provocative tests. 30 patients of FDE were studied. The pattern of fixed drug eruptions, most common class of drug, individual drugs causing positive reaction using provocation tests. Results were analyzed using suitable statistical methods. RESULTS: Drug eruption which is commonest in our study was fixed drug eruption (54.54%). 66.66% of cases had only
more » ... s had only cutaneous lesions. The commonest site of lesion was over limbs (46.66%). Maximum number of patients showed positive reaction on provocative test with oxyphenbutazone followed by sulphamethoxazole. CONCLUSION: This study helps to investigate the drug causing FDR with particular clinical pattern more accurately, especially those with a multi-drug history. Knowledge of these drug eruptions, the causative drugs and the prognostic indicators is essential for clinicians for diagnosis and prevention of adverse drug reactions. Pharmacovigilance activity is significantly effective in increasing the reporting of ADRs.
doi:10.14260/jemds/2015/1304 fatcat:exbibkma2ff45ahzijgzn2oog4