Particle Engineering and Spray Drying Process designing for Solubility Enhancement of Lopinavir

2021 American Journal of PharmTech Research  
To improve the solubility enhancement of solid dispersion of Lopinavir by spray-drying by adding the Soluplus as polymer that is compatible with Lopinavir, was evaluated and the process used for preparation of Spray dried solid dispersion was validated and the 1:3 ratio used for preparation of solid dispersion. Dissolution tests were carried out on several spray dried solid dispersion of Lopinavir and physical mixture. The solid dispersion characterized by DSC, XRD, % Entrapment Efficiency,
more » ... bility study, drug content determination, practical yield, dissolution studies. Keyword: Lopinavir, Soluplus, Spray Drying Technique, Dissolution studies
doi:10.46624/ajptr.2021.v11.i5.004 fatcat:fhd2kuqpmbgofd2fbkx5mc24gm