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Particle Engineering and Spray Drying Process designing for Solubility Enhancement of Lopinavir
2021
American Journal of PharmTech Research
Preserved Fulltext
To improve the solubility enhancement of solid dispersion of Lopinavir by spray-drying by adding the Soluplus as polymer that is compatible with Lopinavir, was evaluated and the process used for preparation of Spray dried solid dispersion was validated and the 1:3 ratio used for preparation of solid dispersion. Dissolution tests were carried out on several spray dried solid dispersion of Lopinavir and physical mixture. The solid dispersion characterized by DSC, XRD, % Entrapment Efficiency,
doi:10.46624/ajptr.2021.v11.i5.004
fatcat:fhd2kuqpmbgofd2fbkx5mc24gm