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Preparation and antitubercular activity of lipophilic diamines and amino alcohols
2009
Memórias do Instituto Oswaldo Cruz
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A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 µg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 µg/mL.
doi:10.1590/s0074-02762009000500006
fatcat:57nh4y5i3jfh7dy46um5ebgwnu