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The Use of Refmac Crystallographic Refinement Program for Detection of Alternative Conformations in Biological Macromolecules
Использование программы кристаллографического уточнения Refmac в процессе выявления альтернативных конформаций в биологических макромолекулах
2012
Математическая биология и биоинформатика
Использование программы кристаллографического уточнения Refmac в процессе выявления альтернативных конформаций в биологических макромолекулах
The analysis of the shifts of atomic centers in unrestrained crystallographic refinement of macromolecular structure enables the detection of alternative conformations of polypeptide chain fragments. Decision-making procedures of the presence or absence of alternative conformations for a particular fragment are based on statistical analysis of atomic shifts obtained during the trial unrestrained refinement of large number of protein structures. The analysis also showed that probability
doi:10.17537/2012.7.692
fatcat:po33ayhmt5fbjjl3ndb625xinq