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The current data explosion is intractable without advanced data management systems. The numerous data sets become really useful when they are interconnected under a uniform interface -representing the domain knowledge. Here we present recent developments at the EBI SRS server (http://srs.ebi.ac.uk). The SRS has become an integration system for both data retrieval and applications for data analysis. It provides capabilities to search multiple databases by shared attributes and to query acrossdoi:10.1093/bioinformatics/18.2.368 pmid:11847095 fatcat:gb2p2ulgpbaxnnkkklfuc6i4ra