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Renal Sodium Excretion Consequent to Pharmacogenetic Activation of Gq-DREADD in Principal Cells
AJP - Renal Physiology
Stimulation of metabotropic Gq-coupled purinergic P2Y2 receptors decreases activity of the epithelial Na ϩ channel (ENaC) in renal principal cells of the distal nephron. The physiological consequences of P2Y 2 receptor signaling disruption in the P2Y2 receptor knockout mouse are decreased Na ϩ excretion and increased arterial blood pressure. However, because of the global nature of this knockout model, the quantitative contribution of ENaC and distal nephron compared with that of upstream renaldoi:10.1152/ajprenal.00612.2018 fatcat:xczqa6ipaffzdoxffkgo4dteu4