The Acari Hypothesis, II: Interspecies Operability of Pattern Recognition Receptors

Andrew C. Retzinger, Gregory S. Retzinger
2021 Pathogens  
Hypersensitivity to galactose-α-1,3-galactose (α-gal) is an informative example of a pathologic IgE-mediated process. By way of their saliva, ticks are able to sensitize humans to tick dietary elements that express α-gal. Mites, which along with ticks constitute the phyletic subclass Acari, feed on proteinaceous foodstuffs that represent most, if not all, human allergens. Given: (1) the gross nature of the pathophysiological reactions of allergy, especially anaphylaxis, (2) the allergenicity of
more » ... acarian foodstuffs, and (3) the relatedness of ticks and mites, it has been hypothesized that human-acarian interactions are cardinal to the pathogenesis of allergy. In this report, a means by which such interactions contribute to that pathogenesis is proposed.
doi:10.3390/pathogens10091220 pmid:34578252 fatcat:azvrbbkfpbgnjincnoy4cngkmy